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Often, the process of creating cancer vaccines is hampered by the passivity of the immune system against antigens of cancer cells, because they are not alien to the body.
At Yale and Klivlendskogm University scientists, along with the Lerner Research Institute in the establishment of vaccination as an antigen has been selected the protein α-lactalbumin, are produced in significant quantities of breast cancer cells, as well as in normal mammary epithelium during lactation (in connection with the use ofmedication during the current or upcoming lactation is contraindicated).
Under experimental conditions, six genetically engineered mice with high predisposition to breast cancer have been exposed to drug administration, α-lactalbumin soderzhaschigo with a substance that enhances the immune response (adjuvant). The same number of animals received a placebo.
For 10 months as a result of the injection, each mouse in the control group were reported development of breast cancer. The grafted animals showed no signs of an absolutely tumor development.
From the words of Vincent Tuohi (Vincent Tuohy), which led the study, the vaccine is supposed to vaccinate women older than 40 years, since breast-feeding at this age is an unlikely scenario, but the risk of cancer grudipovyshaetsya.Tuohi said that, in their view, breast cancer is entirely preventable.
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